Breath Biopsy Guide III cover

Breath Biopsy: The Complete Guide - Third Edition

As science evolves, so must Breath Biopsy®: The Complete Guide. As leaders in the breath research field, we recognise that a lot changes take place from year to year in the technology and research of our community. Our Guide provides you with a handy reference for everything Breath Biopsy related and it’s important to us that it continues to provide the latest findings and innovations. Whether you already have the previous versions of this e-book or you are looking at downloading it for the first time, you will find something new to catch your interest.

The first update you might notice is that we have given Breath Biopsy: The Complete Guide a different look with a new cover. Not only is it new-looking on the outside, we have updated a large amount of the images, tables and graphics inside. You might also notice that it is now longer than the previous version, as we have expanded a lot of the content… continue reading to find out more.

See Guide Contents


1. More Research Results!

There are now so many published studies in the field that we gave them their own chapter. In addition to existing work, the ‘VOC Application Case Study’ chapter has been updated with new content in several disease areas. It now contains examples of how Breath Biopsy and FAIMS technologies have been applied in studies looking at asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension, cancer, inflammatory diseases, infectious diseases and more.

Breath Biopsy is now in use at over 100 clinical sites worldwide and we were not able to include all diseases in detail but don’t miss out the summary table including 15 fascinating studies at the very end of the chapter.

BBGuide v3 - Figure 13
Breath Biopsy: The Complete Guide, Third Edition - sample image

2. Respiratory Droplets

One result of the SARS-CoV-2 pandemic has been growing interest in breath biomarkers from respiratory droplets. We are also exploring Breath Biopsy applications in this area and Breath Biopsy: The Complete Guide introduces this approach. Respiratory droplets are exhaled as breath aerosols, often studied as fine aerosols (<5 microns) and coarse aerosols (>5 microns). They are larger than VOCs and can contain a wider range of biomarker types including proteins, nucleotides and whole viral or bacterial pathogens.

Techniques are being explored to collect breath aerosols that could be integrated into existing analysis pipelines to investigate and detect various illnesses including SARS-CoV-2. You can find more information, including uses for respiratory droplets in page 9 and 10 in the guide.

Types of Biomarkers

3. Breath Biopsy and Liver Disease

With the growing prevalence and severity of liver diseases unrelated to alcohol consumption worldwide, we consider the application of Breath Biopsy to understanding liver disease development and treatment to be a key priority. The list of existing research reporting VOC biomarkers associated with liver diseases continues to grow, and so we have dedicated eight pages of the updated Guide to this topic.

If you are left wanting to find out more after reading the ‘A Test for Liver Disease’ and ‘Probing Metabolism’ sections, join us at the ‘Breath Biomarkers for Liver Disease’ session at the Breath Biopsy Conference 2020.

Sign up to #BBCon20

4. EVOC® Probes and Example Research Applications of EVOC Probes

After you check out the new liver disease section, you might want to have a look at ‘EVOC Probes’ and ‘Example Research Applications of EVOC Probes’ (after all, you don’t need to read it all in one go, and we’ve made changes to help you find the most relevant information for you). EVOC Probes are a specific Breath Biopsy solution that is currently of special interest to liver disease research.

We have dedicated a section of the Guide to Exogenous Volatile Organic Compound (EVOC) Probes because this innovative tool complements biomarker discovery with Breath Biopsy by enabling targeted stimulation of biological pathways. Download the Guide to find out what EVOC Probes are and how they can be applied to your studies using Breath Biopsy. We’ve also included an example of how they can be used to study liver metabolism.

Drug Metabolism Graph

5. Breath Biopsy for Exposomics

Breath Biopsy is being applied to identify the connections between environmental exposure and disease. Exposomics studies involve monitoring people over a lifetime, making them very long-running and creating challenges in producing clear, significant results. Biomarkers for application in exposure research identified using Breath Biopsy would act as indicators of hazardous exposures or pre-clinical signs of elevated disease risk.

The Guide looks more closely at Breath Biopsy for exposomics, as well as giving some examples of the studies being carried out.

Download the Guide

These are just five examples of the new and expanded content in the Breath Biopsy: The Complete Guide. Nearly every section of the guide has been updated, but one thing that has not changed is that this resource is free and accessible to all. We hope that it helps you understand Breath Biopsy, its applications and potential. If you have comments on the Guide or would like to find out more, get in touch.

Breath Biopsy: The Complete Guide on a handheld tablet

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