Celiac disease

Differentiating Celiac Disease From irritable bowel syndrome using Lonestar

Differentiating Coeliac Disease from Irritable Bowel Syndrome by Urinary Volatile Organic Compound Analysis – A Pilot Study

Ramesh P. Arasaradnam, Eric Westenbrink, Michael J. McFarlane, Ruth Harbord, Samantha Chambers, Nicola O’Connell, Catherine Bailey, Chuka U. Nwokolo, Karna D. Bardhan, Richard Savage and James A. Covington

Celiac disease is an autoimmune condition, in which the immune system mistakenly identifies the gluten found in wheat, rye or barley as a threat. The immune response that is triggered in this way damages the small intestine, reducing the body's ability to absorb nutrients from food. Once identified, the effects of celiac disease can be mitigated or even entirely eliminated by adopting a gluten-free diet.

It is believed that around 1 in 100 people in the UK are affected by celiac disease, but there is a great deal of uncertainty surrounding this figure, as many cases may either go undiagnosed or be misdiagnosed. In particular, the symptoms of irritable bowel syndrome (IBS) are very similar to those of celiac disease.

In this pilot study published in PLOS ONE, Arasaradnam et al. used a Lonestar VOC analyzer to analyze changes in the volatile organic compounds in patients' urine in order to differentiate celiac disease cases from IBS cases. They were able to achieve 85% sensitivity and specificity for the identification of celiac disease.

Coeliac IBS heatmap FeaturesHeatmap showing the selected FAIMS features from one of the CV folds. The data are clustered, showing that there
is a clear difference between the celiac disease and D-IBS.

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