Patrick Bossuyt at the Breath Biopsy Conference 2021

KEYNOTE (45 min) - From biomarkers to medical tests: About pitfalls and peaks


The Breath Biopsy Conference 2022 is scheduled for 1st-3rd November. Click the button to express interest in the next Breath Biopsy Conference:

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Talk Abstract:

Progress in unraveling the molecular basis of diseases and biomarkers in many diseases and advances in technology have fueled the search for novel biomarkers in many diseases. There is hope that biomarkers will improve our ability to identify, manage, or prevent a wide range of conditions that jeopardize health. Despite enthusiasm and high prospects for biomarkers, the massive investment has not yet resulted into tangible health benefits for a large number of patients and citizens.

This failure has led to scrutiny. Some have pointed to analytical capacity and limitations of existing measurement methods or the difficulty in finding laboratory professionals with sufficient expertise in applying these laboratory methods. This led to calls for the investment of even more resources into biomarker research and development.

We argue that other, additional explanations, beyond technical caveats, can also account for the current failures to deliver that plague biomarker research. Some of these are not unique for biomarker studies, but apply to biomedical and clinical research in general.

In this presentation, we will discuss the major challenges and hurdles in biomarker research. We will highlight these with examples from the published literature and will discuss how research and development into biomarkers as future tests can be further improved.

Speaker Biography:
Patrick M. Bossuyt is the professor of Clinical Epidemiology at the University of Amsterdam and acts as Chair of the Division of Public Health & Clinical Methods in the Academic Medical Center. His scientific work spans a broad range of topics in clinical research, developed in close collaboration with clinical departments in the Academic Medical Center, with an emphasis on studies of the effectiveness of clinical interventions to guide clinical recommendations and coverage decisions.

Dr Bossuyt leads the Biomarker and Test Evaluation Research program in Amsterdam. The BiTE Program aims to appraise and develop methods for evaluating medical tests and biomarkers, and to apply these methods in relevant clinical studies. In doing so, the program wants to strengthen the evidence-base for rational decision-making about the use of tests and test strategies in healthcare. Bossuyt spearheaded the STARD initiative for the improved reporting of diagnostic test accuracy studies.

Dr Bossuyt has authored and co-authored several hundred publications in peer reviewed journals and serves on the editorial board of a number of these, including Radiology and Clinical Chemistry. He is a member of several national and international advisory committees. He chairs the Scientific Advisory Committee of the Dutch Health Insurance Board, overseeing the national healthcare benefits package.

The Breath Biopsy Conference 2022 is scheduled for 1st-3rd November. Click the button to express interest in the next Breath Biopsy Conference:

Express Interest