Cancer

Non-invasive biomarker discovery with Breath Biopsy® could help to enable early detection of cancer by measuring volatile organic compounds in patients' breath

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Poster: The LuCID study

Detection of lung cancer breath biomarkers via Breath Biopsy in a multi-centre trial

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Article: Every breath counts; Utilizing breath biopsy technology to detect disease early

Mariana Leal, Lead Translational Scientist at Owlstone Medical spoke to News Medical about breath biopsies and how they are a useful tool for investigating biomarkers for the early detection of diseases.

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Poster Presentation: Early Detection of Cancer Conference

Breath-based detection of lung cancer using EVOC targeting β-glucuronidase in the tumour microenvironment

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Presentation: Prof. Robert Rintoul at BBCon 2023

Progress in the development of a Breath Biopsy test for the early detection of lung cancer; The LuCID and Evolution studies

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One in two people will get cancer in their lifetimes. Globally, lung cancer is the most common cancer in the world with over 2 million diagnoses estimated in 2020. If detected early, the chance of surviving cancer is ten times higher, and the cost of treatment is ten times lower than in the later stages. Therefore, developing new ways to detect cancer early is the best way to improve cancer survival.

Our breath test developed to detect lung cancer early is currently being tested in a phase 2 clinical trial and involves the use of an Exogenous Volatile Organic Compound (EVOC®) Probe administered from outside the body to target specific cancer pathways. Our work suggests that almost 90% of Stage I lung cancers can be targeted, with the potential to have a transformative effect on cancer detection.

Breath offers a unique roster of potential biomarkers arising from metabolic pathways in the body that may be disrupted in cancer, that can be collected completely non-invasively. This makes breath an advantageous biomarker matrix to study in comparison to more expensive, more invasively acquired samples such as tissue biopsies that are difficult to tolerate.

Case Studies

A detailed look at some of the research studies investigating biomarkers for different types of cancer.

PARTNERS

We’re working on cancer with these groups:

FURTHER READING

Other recommended reading:

Lung Cancer Infographic

Blog

Articles published on our blog related to cancer.

The Key to Early Detection – Breath Analysis and Mouth Cancer
Case studies of disease areas where breath analysis has been successfully used.
Insights from industry: Interview with News Medical
The Intersection between Cancer and the Microbiome
In vitro analysis could help you identify prospective VOC biomarkers
The potential role of VOCs in detecting and treating lung cancer
The Key to Early Detection – Breath Analysis and Mouth Cancer
Case studies of disease areas where breath analysis has been successfully used.
Insights from industry: Interview with News Medical
The Intersection between Cancer and the Microbiome
In vitro analysis could help you identify prospective VOC biomarkers
The potential role of VOCs in detecting and treating lung cancer