Infectious Disease

Non-invasive biomarker discovery with Breath Biopsy® could help to enable the early detection of infectious diseases by measuring volatile organic compounds in patients’ breath.

Find out more

Poster

Breath Biopsy reveals promising VOC biomarkers for early detection and monitoring of acute pulmonary exacerbations in people with cystic fibrosis.

VIEW THE POSTER

Paper

Detection of Clostridioides difficile infection by assessment of exhaled breath volatile organic compounds

READ PAPER

An infectious disease is an illness caused by a pathogen or its toxic product, which arises through transmission from an infected person, infected animals, or contaminated object to a host. Infectious diseases are responsible for a huge global burden of disease that impacts public health systems and economies worldwide, especially affecting vulnerable populations. Lower respiratory tract infections, diarrheal diseases, malaria, and tuberculosis are among the top causes of overall global mortality.

Exhaled breath contains volatile organic compounds (VOCs) that have originated from many metabolic processes throughout the body. Research has indicated that VOCs present in breath are associated with infectious diseases, and therefore show promise as non-invasive biomarkers. Pathogenic microbes can alter the VOCs in breath either through altered metabolic pathways due to the host immune response, or with certain pathogens like bacteria and fungi, their own endogenous metabolic processes. VOCs originating from infection sites all over the body can be exchanged from the bloodstream into the air in the lungs at the alveolar membrane and exhaled in breath.

Some infectious diseases predominantly affect the lungs and other tissues in the respiratory tract such as the nose and throat. As breath is in direct contact with these tissues, analysis of breath can provide a better insight into local respiratory diseases as opposed to blood or urine which are more indirect. Biomarkers of infectious diseases are often investigated in clinical settings using invasive techniques, such as blood tests. Exhaled breath offers a unique roster of potential biomarkers arising from an infection and can be collected completely non-invasively. This makes breath an advantageous biomarker matrix to study in comparison to more expensive, more invasively acquired samples that are difficult to tolerate.

Case Studies

A detailed look at some of the research studies investigating biomarkers for infectious diseases.

PARTNERS

We’re working on infectious diseases with these groups:

FURTHER READING

Other recommended reading:

Blog

Articles published on our blog related to infectious diseases.

Breath VOC Analysis as an Innovation to Fight Infectious Diseases: Malaria
Breath Analysis: A Potential Ally for Cystic Fibrosis
Explore Tuberculosis Through the Power of Breath Analysis.
Breath Analysis: A Game-Changer in Early Invasive Aspergillosis Detection?
Breath VOC Analysis as an Innovation to Fight Infectious Diseases: Malaria
Breath Analysis: A Potential Ally for Cystic Fibrosis
Explore Tuberculosis Through the Power of Breath Analysis.
Breath Analysis: A Game-Changer in Early Invasive Aspergillosis Detection?

Talk to us about your biomarker research and how Breath Biopsy could help.