PAN

Early Detection of biomarkers in multiple cancers

Overview

Detecting Cancer Early

The aim of the PAN cancer study is to evaluate the potential of Breath Biopsy to detect various types of cancer by profiling Volatile Organic Compounds (VOCs) on breath. This serves as a first step in a research program evaluating the use of a breath test in early detection of cancer. 

The key parameter driving survival chances in patients with cancer is the stage at which the cancer is detected. Detection of cancer at its earliest stages, when it can be treated with curative intent, results in a dramatic improvement of survival rates whilst reducing treatment cost. Unfortunately, over half of cancers are detected when disease is more advanced, as early stages of cancer are typically asymptomatic. Internationally this paradigm has resulted in the implementation of national screening programs for breast, cervical, colorectal and lung cancer. The degree to which such programs have been implemented varies widely as they are typically associated with high costs, can be invasive and produce a high number of false positives results with consequent undesirable follow-up procedures and high resource utilisation. This has sparked ongoing debate about the utility of some of these programs and has prevented implementation of others. Therefore, there is a clear need for a low-cost, non-invasive and accurate test for early detection across a range of cancers.

The PAN study is a collaborative effort between Cambridge University Hospital NHS Foundation Trust, University of Cambridge, Cancer Research UK (CRUK) and Owlstone Medical.

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ReCIVA is a reliable and reproducible way to capture VOC biomarkers in breath samples

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Cancer Types

The Six Cancers in the PAN study

PAN Cancer 6 types 300px wdth The PAN study will focus on six cancer types and will initiate them over three staggered phases.
  • Oesophageal
  • Gastric
  • Pancreatic
  • Renal
  • Bladder
  • Prostate

Study Process

How will the study work?

Subjects will be recruited from Cambridge University Hospitals by local research staff. Breath samples will be collected by means of the ReCIVA breath sampler which requires tidal breathing into a face mask for around 10 minutes. A cancer free control subject matched for age, sex and tumour specific risk factors will be recruited and sampled. Breath samples will be shipped to Owlstone Medical's central laboratory for analysis of breath biomarkers.

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Subjects

Study Subject Population

The study will recruit patients with confirmed cancer and control patients without cancer for each of the 6 cancer types. There will also be an additional group of healthy patients that will provide further validation and data collection for analysis.

Protocol Summary

Summary of the Study Protocol

  • Design

    This study will be investigating subjects that have one of the 6 selected cancer types and comparing them to a pool of control subjects.

  • Primary Outcome

    Evaluating the potential of Breath Biopsy in the early detection of various types of cancer by profiling volatile organic compounds (VOCs) on breath.

  • Breath Analysis

    Breath samples will be collected on-site using the ReCIVA breath sampler device and it's collection station. The samples will then be analysed at Owlstone Medical's central laboratory in Cambridge, UK.

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