An absolute quantification of microbial metabolites
INTRODUCTION
The Breath Biopsy® Microbiome Panel
Our Breath Biopsy Microbiome panel offers precise quantification of key metabolites in exhaled breath originating from the gut microbiome previously reported in the literature to have a range of associations with health and disease.
Analysing microbiome derived functional metabolites in exhaled breath offers some key advantages over other methods including:
- Improved subject recruitment and retention due to the inconvenient / unpleasant nature of stool and blood sampling.
- Real-time, longitudinal insights into microbial activity, independent of gut transit time, to enable assessment of the effects of dietary or other interventions including probiotics.
- Ability to understand microbial-host interactions by analysing absorbed metabolites versus what’s excreted in stool samples.
You can learn more about the constituents of this panel in the table below:
If you are interested in incorporating breath biomarkers into your research, the Microbiome Panel is the perfect way to begin. For those interested in learning more, we have some useful content discussing VOC biomarkers, the fundamentals of breath analysis and why microbiome-derived compounds appear in breath and how we measure them. The gut microbiome, alongside the linear connection to gastrointestinal research, can also influence many other disease states, so can also be useful for those conducting respiratory, infection or metabolic studies.
Features
The Panel includes:
- Lease of the Breath Biopsy Collection Station for the duration of your study – enabling reproducible breath sample collection at the clinical site to maximize signal to noise ratio.
- TD-GC-MS analysis using high-resolution accurate mass (HRAM) Q Exactive Orbitrap systems within our laboratories.
- A quantitative data report on the Panel volatile microbial metabolites that are routinely seen in exhaled breath with reference datasets available in the Breath Biopsy VOC Atlas®. These are presented in table format including compound IDs. These data are supplemented with statistical analysis to investigate specific study objectives, delivered by Owlstone’s expert in-house breathomics team.
The panel is priced per sample, please get in touch for further information.
