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Breath Biopsy Services

Combining high resolution accurate mass mass spectrometry and world-leading breath analysis expertise to offer complete biomarker discovery and validation solutions

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Introduction

Enabling early disease detection and precision medicine across a wide range of disease areas

Through Breath Biopsy® Services we can support every aspect of your breath biomarker research. From trial design through to analysis, test development and validation, our experienced team can help. We recommend accessing our services as part of Breath Biopsy OMNI, our most advanced solution for reliable on-breath global biomarker discovery including optimized methods for sample collection and analysis.

As a user of Breath Biopsy Services, all of your breath sample processing and analysis will be handled by our expert team at the world’s only specialist high-volume Breath Biopsy Laboratory in Cambridge, UK. 

Our analytical pipeline centers on high resolution accurate mass (HRAM) mass spectrometry (MS) provided by Q Exactive™ Orbitrap™ technology and includes rigorous quality control at all stages to ensure you get the best possible results. Biomarker identification uses the optimized HRAM Breath Biopsy Library to give high confidence molecular identities.

Breath Biopsy Products and Services are for research use only. Not for use in diagnostic procedures.

The Breath Biopsy Laboratory

More Breath Biopsy Summary Stats

Service Capabilities

  • Sensitivity

    High sensitivity prospective breath biomarker detection

  • Versatility

    Service options available for focused and VOC discovery analysis to suit your needs

  • Precision

    HRAM mass spectrometry VOC analysis

  • Customization

    Data processing options to include in-depth statistical analyses and modelling

  • Accuracy

    Tailored HRAM Breath Biopsy Library of VOCs provides confidence in VOC identification

  • Disease Relevant

    Prospective biomarkers with reported relevance to a range of key disease processes, including inflammation

  • Quality

    Rigorous quality control standards

  • Interpretation

    Biological interpretation and relevance analysis

Explore the Applications of Breath Biopsy for Early Detection, Precision Medicine and Exposure

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OMNI flowchart

Breath Biopsy OMNI

By optimizing breath collection and analysis, we have developed Breath Biopsy OMNI, our most advanced solution for reliable on-breath global biomarker discovery. OMNI has been developed to maximize compound detection and minimize process variability, ensuring high-confidence biomarker discovery that allows rapid compound identification.

Our methods, specifically assess on-breath compounds, helping to verify that detected compounds have biological relevance and are not simply reflective of ambient factors. Our HRAM Breath Biopsy Library also offers high-confidence prospective identification for many on-breath compounds.

Breath Biopsy Services let you choose analysis and reporting options to suit your needs

Your Breath Biopsy Service Options

Every breath research project is different and has its own set of needs and requirements. Our Breath Biopsy Services can be adapted to suit the specifics of your study, reflecting your field of interest, resources, budget and access to expertise.

Breath Biopsy OMNI is our complete solution for global biomarker discovery, including comprehensive analysis and VOC identification with high-confidence identify assignments matched from the HRAM Breath Biopsy and NIST libraries.

Results include a raw feature table with relative quantifications of all analyzed compounds. Should you wish, you can also request additional data analysis and reporting for your study. Reporting is provided at two levels, Standard and Comprehensive, and includes statistical analyses, modelling and biological interpretation. Talk to our team to find out which option best suits your needs.

More about reporting

Discover the the only commercial biomarker platform optimized for on-breath global VOC analysis

Explore Breath Biopsy OMNI
Diagram showing elements of OMNI analysis
How the HRAM Library and VOC Panels support VOC Identification in the Breath Biopsy OMNI Assay

HRAM Breath Biopsy Library

The HRAM Breath Biopsy Library provides reliable breath biomarker identification optimized for Breath Biopsy samples. VOCs included in the Library have relevance to factors including inflammation, oxidative stress, respiratory disease, cancer, liver disease, the microbiome or environmental exposures. Each association is supported by a combination of biological rationale, mechanistic relationships and strong empirical evidence.

All VOC included in our panels are supported by robust evidence

RUO Panel for Respiratory Diseases

We developed our Panel to drive meaningful advances in biomarker research on respiratory diseases. Quality biomarker research requires high confidence biomarker identification and clear evidence of biological relevance. The Breath Biopsy Panel for Respiratory Diseases consists of a curated set of VOC biomarkers on breath that can be reliably identified through the HRAM Breath Biopsy Library and that show demonstrable associations to respiratory diseases and disease processes.

The Panel can support research to characterize disease endotypes, provide disease monitoring and measure therapeutic responses. Panel VOCs can be analyzed with our focused or discovery Service options of the OMNI Assay. We also provide a range of options for data interpretation and reporting to fit the needs and requirements of your study.

More Details about the Panel

Fidn out about the specific VOCs included in the panel by downloading our poster:

Show me the Panel VOCs

Breath Biopsy for Respiratory Diseases - Marc van der Schee explores case studies from asthma, COPD and other conditions

WATCH WEBINAR On-DEMAND
Breath Biopsy for Respiratory Diseases - On-demand Webinar graphic on laptop screen
Photo of Thermo Orbitrap

What is GC-Orbitrap?

The Breath Biopsy Laboratory includes multiple Thermo Scientific Q Exactive GC Hybrid Quadrupole-Orbitrap mass spectrometers, enabling high-accuracy analysis of breath samples for biomarker discovery and targeted validation.

Find out more from Thermo Fisher Scientific:

Explore Orbitrap

Orbitrap for Breath Biopsy

  • Optimized

    To enable high-quality VOC detection from breath samples

  • Sensitivity

    Capable of detecting low abundance analytes in a complex breath matrix

  • Dynamic Range

    Detect both high-abundance VOCs and trace-level analytes within a single analysis. Typical concentrations of chemicals in breath span 5 orders of magnitude.

  • Reliable

    Accurate mass stability and spectral fidelity leads to fast and confident detection.

  • Software

    Software flexibility for discovery and routine targeted workflows.

Breath Biopsy: The Complete Guide, your introduction to breath biomarkers

DOWNLOAD FREE EBOOK
Breath Biopsy: The Complete Guide on a handheld tablet
women using ReCIVA breath sampler

With you at every stage

As the leaders in Breath Biopsy, we’re equipped to help you at every stage of your investigations. Thanks to our role in some of the world’s largest breath research trials, our team includes authorities on study design and planning. We offer study management and training to implement your studies in clinical sites worldwide.

 

Developing clinical applications

Beyond biomarker discovery and validation, we can work with you to develop identified biomarkers into focused breath-based tests for clinical implementation. We have the capabilities to work with you to develop your research further through fit-for-purpose quantitative TD-GC-MS assays or our proprietary field asymmetric ion mobility spectroscopy (FAIMS) solutions.

FAIMS combines high sensitivity, tuneable chemical detection with versatility and portability making it suitable for application in a range of point of care clinical settings. Together, we can develop tests for use in screening, early detection, complementary diagnostics, treatment monitoring and much more.

Hear the latest results and build connections in the breath research community at the next Breath Biopsy Conference

Details on the Breath Biopsy Conference Register Interest
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The Breath Biopsy Laboratory

Inside the Breath Biopsy Laboratory

Get in touch with Owlstone

Get in touch with our team to discuss how we can work together

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