Breath Biopsy Services
Combining high resolution accurate mass mass spectrometry and world-leading breath analysis expertise to offer complete biomarker discovery and validation solutions
Introduction
Enabling early disease detection and precision medicine across a wide range of disease areas
Through Breath Biopsy® Services we can support every aspect of your breath biomarker research. From trial design through to analysis, test development and validation, our experienced team can help.
As a user of Breath Biopsy Services, all of your breath sample processing and analysis will be handled by our expert team at the world’s only specialist high-volume Breath Biopsy Laboratory in Cambridge, UK.
Our analytical pipeline centers on high resolution accurate mass (HRAM) mass spectrometry (MS) provided by Q Exactive™ Orbitrap™ technology and includes rigorous quality control at all stages to ensure you get the best possible results. Biomarker identification uses the optimized HRAM Breath Biopsy Library to give high confidence molecular identities.
Breath Biopsy Products and Services are for research use only. Not for use in diagnostic procedures.
The Breath Biopsy Laboratory
Service Capabilities
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Sensitivity
High sensitivity breath biomarker detection
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Versatility
Service options available for focused and VOC discovery analysis to suit your needs
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Precision
HRAM mass spectrometry VOC analysis
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Customization
Data processing options to include in-depth statistical analyses and modelling
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Accuracy
Tailored HRAM Breath Biopsy Library of VOCs provides confidence in VOC identification
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Panels
A curated RUO Panel of VOCs is available to support focused research into respiratory diseases
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Quality
Rigorous quality control standards
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Interpretation
Biological interpretation and relevance analysis
Explore the Applications of Breath Biopsy for Early Detection, Precision Medicine and Exposure
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Breath Biopsy OMNI Assay
The Breath Biopsy OMNI (Owlstone Medical Novel Insights) Assay is our comprehensive solution for end-to-end breath sample collection and VOC analysis. Thanks to the unique capabilities of our platform, we are able to provide untargeted VOC discovery and focused VOC analyses using a single set of breath samples.
The implementation of our HRAM Breath Biopsy Library ensures you can have high confidence in biomarker identifications. This can be combined with VOC discovery to identify additional novel candidate VOCs relevant to your application. Our thorough system of internal standards offers accurate relative quantitation for all identified breath compounds.
We provide a range of analysis and reporting options to suit your needs and study design. Options range from raw feature tables through to comprehensive statistical analysis and modelling supported by machine learning methods.
Your Breath Biopsy Service Options
Every breath research project is different and has its own set of needs and requirements. Our Breath Biopsy Services can be adapted to suit the specifics of your study, reflecting your field of interest, resources, budget and access to expertise.
You can choose between focused or discovery services. Our focused service analyses all VOCs in the HRAM Breath Biopsy Library and includes a selection of compounds with known relevance as breath biomarkers. The discovery service is more extensive, including comprehensive analysis and VOC identification with high-confidence IDs matched from the HRAM Breath Biopsy and NIST libraries. In either case, you will receive a raw feature table with relative quantifications of all analyzed compounds.
Should you wish, you can also request additional data analysis and reporting for your study. Reporting is provided at two levels, Standard and Comprehensive, and includes statistical analyses, modelling and biological interpretation. Talk to our team to find out which option best suits your needs.
Get advice from our experts on designing robust clinical studies
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HRAM Breath Biopsy Library
The HRAM Breath Biopsy Library provides reliable breath biomarker identification optimized for Breath Biopsy samples. VOCs included in the Library have relevance to factors including inflammation, oxidative stress, respiratory disease, cancer, liver disease, the microbiome or environmental exposures. Each association is supported by a combination of biological rationale, mechanistic relationships and strong empirical evidence.
RUO Panel for Respiratory Diseases
We developed our Panel to drive meaningful advances in biomarker research on respiratory diseases. Quality biomarker research requires high confidence biomarker identification and clear evidence of biological relevance. The Breath Biopsy Panel for Respiratory Diseases consists of a curated set of VOC biomarkers on breath that can be reliably identified through the HRAM Breath Biopsy Library and that show demonstrable associations to respiratory diseases and disease processes.
The Panel can support research to characterize disease endotypes, provide disease monitoring and measure therapeutic responses. Panel VOCs can be analyzed with our focused or discovery Service options of the OMNI Assay. We also provide a range of options for data interpretation and reporting to fit the needs and requirements of your study.
More details on the Panel and the VOCs it includes are available by downloading our poster:
Breath Biopsy for Respiratory Diseases - Marc van der Schee explores case studies from asthma, COPD and other conditions
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What is GC-Orbitrap?
The Breath Biopsy Laboratory includes multiple Thermo Scientific Q Exactive GC Hybrid Quadrupole-Orbitrap mass spectrometers, enabling high-accuracy analysis of breath samples for biomarker discovery and targeted validation.
Find out more from Thermo Fisher Scientific:
Orbitrap for Breath Biopsy
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Optimized
To enable high-quality VOC detection from breath samples
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Sensitivity
Capable of detecting low abundance analytes in a complex breath matrix
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Dynamic Range
Detect both high-abundance VOCs and trace-level analytes within a single analysis. Typical concentrations of chemicals in breath span 5 orders of magnitude.
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Reliable
Accurate mass stability and spectral fidelity leads to fast and confident detection.
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Software
Software flexibility for discovery and routine targeted workflows.
Breath Biopsy: The Complete Guide, your introduction to breath biomarkers
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With you at every stage
As the leaders in Breath Biopsy, we’re equipped to help you at every stage of your investigations. Thanks to our role in some of the world’s largest breath research trials, our team includes authorities on study design and planning. We offer study management and training to implement your studies in clinical sites worldwide.
Developing clinical applications
Beyond biomarker discovery and validation, we can work with you to develop identified biomarkers into focused breath-based tests for clinical implementation. We have the capabilities to work with you to develop your research further through fit-for-purpose quantitative TD-GC-MS assays or our proprietary field asymmetric ion mobility spectroscopy (FAIMS) solutions.
FAIMS combines high sensitivity, tuneable chemical detection with versatility and portability making it suitable for application in a range of point of care clinical settings. Together, we can develop tests for use in screening, early detection, complementary diagnostics, treatment monitoring and much more.
Hear the latest results and build connections in the breath research community at the next Breath Biopsy Conference
Details on the Breath Biopsy Conference Register Interest
The Breath Biopsy Laboratory
Inside the Breath Biopsy Laboratory
