Lonestar VOC Analyzer

A non-invasive, easy to use analyzer for the detection of disease biomarkers in clinical samples

  • Rapid, sensitive and selective VOC analyzer
  • Untargeted discovery and targeted analysis of disease biomarkers
  • Cost-effective and easy to use for both clinicians and researchers
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Overview

Disease Biomarker Detection with the Lonestar VOC Analyzer

Volatile organic compounds (VOCs) are the end product of metabolic processes in the body that are related to diseases. These VOCs travel via the bloodstream, ending up in exhaled breath. Using FAIMS technology, the Lonestar VOC Analyzer can analyze breath samples for the detection of disease biomarkers related to infections, inflammatory diseases and cancers. Our customers include GSK, Samsung, and the UK National Health Service, among many others.

 

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  • Highly sensitive

    High sensitivity with part per billion detection levels combined with inlet control for high dynamic range

  • Rapid screening

    Ideal for rapid screening of samples

  • Highly versatile

    Compatible with various clinical samples - breath, urine, stool, blood, sweat, sputum

  • Cost-effective

    Cost-effective and easy to use for both clinicians and researchers

  • Targeted Analysis

    Selective screening for target compounds

  • Sensors guided stability

    Integrated temperature, flow and humidity sensors for stable, closed-loop operation

  • Connectivity

    Network and wireless connectivity for remote monitoring and operation

  • Easy integration

    Easy integration of other sensor data and control of third party systems

  • Powerful software

    Powerful custom software for data visualisation, real-time control and offline analysis

Have a question about how to use the Lonestar VOC Analyzer in your own research?

Contact our team or view our support portal

How it works

Sample Introduction

Breath samples are collected using Owlstone’s ReCIVA Breath Sampler, and are captured on Breath Biopsy Cartridges. The cartridges are then placed into a thermal desorption (TD) system, which carries out a controlled heating process to release the captured VOCs into the Lonestar VOC Analyzer for analysis.

Sample Analysis

The released VOCs go through an initial separation stage on a Gas Chromatography (GC) column. They then arrive at the FAIMS chip, where they are further separated and identified by means of their relative mobilities. The Lonestar VOC Analyzer can also be used to analyze solid and liquid samples, by replacing the TD and GC steps with the ATLAS sampling module.

Learn about FAIMS technology

Studies have shown that the Lonestar VOC Analyzer can be used to predict loss of control in Asthma

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Reproducibility

Reliable Collection and Analysis of Breath Samples

Reproducibility is key for any analytical technique, and extensive testing has been carried out to ensure that the Lonestar VOC Analyzer, when used with the ReCIVA Breath Sampler, allows for consistent collection and analysis of breath VOCs. This is of particular importance when conducting studies that involve the collection of multiple samples, at multiple different sites and timepoints, such as Owlstone Medical's LuCID trial.

The figure to the left shows chromatograms of VOCs in breath samples collected on independent VOC sample tubes using the ReCIVA Breath Sampler and analyzed using the Lonestar VOC Analyzer. High reproducibility is observed within a single breath collect (i and ii). Small changes in the chromatogram are observed between different breath collects performed on the same individual (iii), which is to be expected because some VOCs in breath do vary over time.

We have worked with a number of eNose platforms for medical breath research and we have found Owlstone’s FAIMS technology and Lonestar instrument to provide very good accuracy.

Professor Peter Sterk
University of Amsterdam

We have been using FAIMS for almost five years and have found it able to non-invasively detect a broad range of diseases, including cancer, with high sensitivity and specificity

Professor James Covington
University of Warwick

Research case studies

Real-world applications of the Lonestar VOC Analyzer

Research teams around the world have already discovered the unique potential of FAIMS. Published studies cover the spectrum from cancer (bowel/colorectal) to inflammatory diseases (such as IBD) to infectious diseases (C. difficile).

Breath Biopsy® Complete Guide - VOCs as Biomarkers for Disease

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Data analysis

Open data format and off the shelf multi-variate analysis tools

Owlstone Medical work with new FAIMS users to develop sample and data analysis methodologies. The Lonestar VOC Analyzer uses an open data format, allowing users to also use off the shelf multi-variate analysis tools. Raw FAIMS spectra are produced from the analysis of clinical samples. FAIMS spectra are multi-dimensional and extremely rich in information, so typically techniques such as discrete wavelet transforms or principal component analysis are required to extract the distinguishing features of those patients suffering from specific illnesses vs. healthy individuals.

A model (such as the OPLS-DA model, left) or classification algorithm is then developed and applied to the reduced data set. This algorithm tests relevant features of the data, and assigns each sample to the disease or disease-free category. The form of the classifier depends upon the data-set, but random forest, sparse logistic regression and support vector machines have all been successfully deployed. The classifier is then ideally tested on a new set of samples, to externally validate the sensitivity and specificity.

Use Lonestar VOC Analyzer with our 1.0 Breath Biopsy® Collection Kit

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Specs

Lonestar VOC Analyzer Technical Specifications

  • Technology

    Field Asymmetric Ion Mobility Spectrometry

  • Detection Mode

    Positive and negative ions

  • Sample Input

    Ambient, Headspace

  • Inlet / Outlet

    1/8 Swagelok compression fittings

  • Analyte Range

    Volatile Organic Compounds

  • Dynamic Range

    User adjustable inlet dilution for ppb - %

  • Required Gas Supply

    Clean, dry air (there is an integrated, replaceable scrubber)

  • Max Heater Temperature

    70C

  • Humidity Range

    0% - 95%

  • Instrument Sensors

    Temperature, humidity, flow and pressure

  • Inputs

    Inbuilt tracker ball

  • Output

    Real-time chemical spectra and stored data

  • Computer

    Inbuilt PC running Windows XP

  • Memory

    4gb internal

  • Comms

    USB, RJ45

  • Software

    Custom online control software

  • AC Inputs

    120/240V AC

  • Dimensions

    383 x 262 x 195 mm

  • Weight

    7.8kg

Get in touch with the Owlstone team for further information and pricing

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