Breath Biopsy® OMNI®
The most advanced solution for reliable global breath VOC analysis
- An end-to-end optimized service for consistent breath analysis
- Reliable breath collection and analysis methodologies
- Maximized for reproducible detection of biorelevant compounds
- Supported by study design, management and data interpretation expertise
Introduction
The breath volatile organic compound (VOC) global analysis service
Breath Biopsy OMNI delivers comprehensive and robust global breath VOC analysis, encompassing expertise in study design and optimized sample collection, analysis and interpretation procedures. OMNI is rigorously tested at all stages to provide high-confidence results that support biomarker identification and validation.
-
On-breath VOC detection
Optimized to maximize number of detectable VOC species on breath.
-
Reliable sampling
ReCIVA and CASPER ensure standardized, non-invasive VOC sample collection.
-
Precision analysis
Chemical analysis using high-resolution accurate mass TD-GC-MS, followed by custom univariate and multivariate statistical approaches.
-
Reporting & Interpretation
Our HRAM VOC library and VOC Atlas support high-confidence compound identification, with biological data collated for comparison across studies and against published literature.
-
Committed to quality
Extensive internal standards ensure consistent quality throughout and help to facilitate subsequent biomarker quantitation and identification.
-
Standards included
8 internal standards in every sample to assess analytical performance. An additional 52 calibration standards included in every analytical sequence.
Why OMNI?
Why OMNI?
Exhaled breath is a rich source of prospective clinically-relevant biomarkers. Several are already in widespread use, including oxygen, carbon dioxide, hydrogen, methane, nitric oxide and sulfur compounds, yet many more remain to be discovered. Breath contains over 1,000 VOCs of which many have links to metabolism and disease processes, and some have the potential to become biomarkers for disease detection and precision medicine.
Breath offers many possible advantages in terms of non-invasive collection, ease of use, relevance to a wide range of clinical needs. Yet the complexity of breath and potential for ambient contamination has made reproducible analysis challenging.
Breath Biopsy OMNI is the only commercial biomarker platform optimized for on-breath global VOC analysis. If you’re seeking a method for non-invasive global biomarker research that provides easy, flexible sample collection, high resolution compound analysis and reproducible results that you can trust then talk to us about OMNI.
Getting started with Breath Biopsy
Transform your research workflow
What is Breath Biopsy OMNI?
How can Breath Biopsy OMNI help me?
What advantages does breath have over other samples?
What compounds can Breath Biopsy OMNI detect?
What are 'on-breath' biomarkers?
Many biomarker research studies report on the number of features detected during analysis, or the number of identified compounds. Breath research studies often report hundreds of compounds in each breath sample, but many of these could originate from external and ambient sources and may have no relevance to a patient’s biology. This adds to the noise in the system and reduces the chance of finding robust biomarkers that will survive validation and could have clinical relevance. We've used what we've learned from our own studies to create the Breath Biopsy VOC Atlas, a catalogue of identified VOCs that are commonly found on breath within a heterogenous healthy population.
OMNI utilizes a clear definition of on-breath compounds to optimize detection, and has been thoroughly tested to ensure reproducibility in compound detection.
Biomarkers backed by biology
OMNI has demonstrated the capability to repeatably measure VOCs from breath including molecules with known associations to a range of metabolic pathways and disease mechanisms. Detected compounds include alcohols, ketones, aldehydes and alkanes and have been linked to conditions including chronic respiratory diseases, liver diseases and inflammation, which are collated in our Breath Biopsy knowledge base.
The sensitivity afforded by HRAM mass spectrometry, Breath Biopsy sample collection and our custom data analysis allows the detection of dozens of very low abundance breath VOCs that have yet to be widely studied and have equal potential as biomarkers.
The detection of the combination of well-known biologically relevant as novel VOCs makes OMNI the most comprehensive platform for VOC biomarker studies.
Breath Biopsy OMNI for reliable detection of VOC biomarkers
Watch on demand now
Optimized at all Stages
OMNI ensures optimized discovery at all stages
We have analyzed and optimized stages throughout the biomarker pipeline to ensure maximal compound detection and minimized process variation during sample collection, processing and data analysis. Find out more in the sections below.
Breath sample collection
The Breath Biopsy Collection Station including ReCIVA® Breath Sampler standardizes collection of VOCs from breath and ensures easy, robust sample storage and transportation using Breath Biopsy Cartridges of sorbent tubes.
The Breath Biopsy Collection Station
The Collection Station and Breath Biopsy Kits provide:
- High-sensitivity, standardized breath sample collection and VOC pre-concentration
- Exclusion of ambient VOCs to enhance signal-to-noise and minimize false discovery
Breath sample processing
Samples are analysed using Breath Biopsy Services in the world’s only specialist Breath Biopsy Laboratory. We use a custom pipeline built around high-resolution accurate mass (HRAM) gas chromatography mass spectrometry (GC-MS). Our quality assurance process is accredited to ISO-9001 standard to help ensure all samples are processed to the same high level of quality and consistency.
OMNI processing and analysis includes:
- Capability to reliably detect breath VOCs and facilitate compound identification and validation
- Compound detection based on high-resolution accurate mass (HRAM) Orbitrap mass spectrometry, sensitive to ppb levels
- Compound identification through bespoke our Breath Biopsy HRAM Library (including reference to the VOC Atlas), and generic NIST library matching
- Access to in-house expertise on study design, clinical study management, statistical analysis and result interpretation
Reporting and interpretation
We have developed our own HRAM Breath Biopsy Library of over 400 compounds detected using Breath Biopsy and the VOC Atlas of compounds that are commonly found on breath within a heterogenous healthy population. The Library and the Atlas enable high confidence identification of compounds from the results of our GC-MS analysis. All OMNI studies result in a comprehensive feature table including compound IDs obtained through reference to the Breath Biopsy HRAM Library, VOC Atlas or comparison to online NIST data.
Depending on your needs, we can also provide detailed reporting and expert interpretation to support the results of your study. This can include thorough statistical analysis, both uni- and multivariate analysis, designed to address your scientific questions, accompanied with biological and clinical interpretation of observed results based on established knowledge and published scientific literature.
Breath Biopsy® OMNI®: advanced global breath VOC analysis
Download whitepaper
(If you are unable to see this form please check your browser's Privacy Settings and make sure you are not blocking cookies. If you are still having problems seeing this form, please contact us at breathbiopsy@owlstone.co.uk)
You can opt out at any time using the link provided in our emails. For more information, please refer to our Privacy Policy
