ReCIVA® Breath Sampler

A reliable and reproducible way to capture VOC biomarkers in breath samples

  • Exhaled breath Volatile Organic Compounds (VOCs) are collected on a Breath Biopsy Cartridge for later analysis
  • High patient safety and comfort
  • CE marked and in use in over 90 academic research groups and clinical labs around the world
Download ReCIVA Spec Sheet


In the burgeoning field of breath research, a key requirement is the ability to reliably and reproducibly capture breath samples for analysis

Developed in conjunction with a multi-disciplinary group of researchers, the ReCIVA Breath Sampler provides an out-of-the-box means of reliably and reproducibly capturing breath samples for analysis. This allows researchers to focus their efforts on analyzing the captured breath. The system is currently being deployed as part of Owlstone Medical's LuCID Clinical Trial for lung cancer detection.

Depending on the particular disease under investigation, the VOCs of interest could be present in different breath fractions. Pressure and CO2 sensors in ReCIVA provide real-time monitoring of the patient's breathing, allowing the relevant fractions to be selected. Fast sensor response ensures the required breath fraction is accurately collected, and the sampler is constructed using inert materials to minimize contamination of the breath sample by exogenous VOCs.

Different breath fractions can be stored independently within the Breath Biopsy Cartridge, which can be analyzed immediately or stored for later use. The Breath Biopsy Cartridge ensures reproducible collection of volatile biomarkers, unlike other commonly used breath collection media.

The ReCIVA Breath Sampler has been designed with patient comfort and safety as top priorities. Requiring only simple tidal breathing and minimal effort, high patient comfort has been reported whilst using the ReCIVA Breath Sampler. Built using easily cleaned, high quality inert materials the ReCIVA minimizes cross contamination and maximizes patient safety by incorporating a disposable, single use mask and an integral filter.


  • Repeatable and reproducible sampling

    Ideal for longitudinal studies measuring breath VOCs over time

  • High patient safety and comfort

    Simple tidal breathing is straightforward for patients to perform

  • Pre-concentrates samples for later analysis

    Breath Biopsy Cartridges can be analyzed immediately or stored

  • Compatible with gas chromatography

    Compatible with platforms including GC-FAIMS and GC-MS (minor modifications to ensure compatibility)

  • Flexible breath collection

    Allows selection of different volumes and fractions (end-tidal, inhaled, bronchial) of breath

  • Minimizes cross-contamination

    Disposable single-use masks and integral filter minimize risk of cross-contamination

Breath Biopsy® Complete Guide - VOCs as Biomarkers for Disease


How it works

Designed in collaboration with over 100 leading breath diagnostics researchers

Reproducibility is key for any analytical technique, and standardization of sample collection is a vital step in maximizing the comparability of results from different methods of chemical analysis. The Breathe Free Consortium is a multi disciplinary expert discussion forum that was formed by Owlstone Medical to develop a standardized design for a breath sampler that will provide a benchmark for the collection of breath samples for chemical analysis and medical diagnosis. The ReCIVA is a CE marked and validated, commercially available Breath Sampler manufactured by Owlstone Medical. ReCIVA enables robust, reproducible breath sampling, ideal for longitudinal monitoring of breath VOCs over time.   

Monitor patient breathing patterns in real time

Using internal, fast response CO2 and pressure sensors ReCIVA can monitor patient breathing patterns in real time (see left). This allows it to track when particular parts of the patient's breath (e.g. end-tidal or bronchial fractions) are being exhaled. The supplied software can then be used to turn the sampling pumps on and off at the necessary time to collect the required fraction.

Getting the full picture through a straightforward software interface

Using the straightforward software interface (see right), the following fractions can be selected: upper airways only, lower airways only, upper and lower airways, whole breath (including mouth air) and upper airways including mouth air. Selected volumes and fractions of exhaled breath VOCs are collected a Breath Biopsy Cartridge for later analysis. Replicate breath samples and/or different breath fractions can be obtained in a single collection event.

ReCIVA Pediatric Masks

The ReCIVA Breath Sampler is available with adult and child-sized masks, both of which have been CE marked. The pediatric mask extends the range of ages that can be sampled down to around 5 years old. The non-invasive nature of breath testing makes it a particularly attractive option for use with younger patients, who may be reluctant to give e.g. a blood sample. The masks have opened up a whole new range of research possibilities, and are already being deployed in studies of childhood asthma.

A comprehensive collection of insightful infographics, posters and multimedia at your disposal

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Data analysis

Analysis of breath sample chemical composition

ReCIVA is used to collect breath samples onto Breath Biopsy Cartridges for later analysis. ReCIVA is ideal for use in conjunction with techniques such as GC-MS (gas chromatography-mass spectrometry) and GC-FAIMS (gas chromatography field asymmetric ion mobility spectrometry), and can be easily configured to supply defined breath volumes and fractions, allowing straightforward comparison between, for instance, end-tidal and bronchial breath fractions. Concentrations of endogeneous VOCs are up to three times higher in gas from the alveoli (the end-tidal fraction) than mixed expiratory gas and alveolar samples are also less prone to contamination. The use of Breath Biopsy Cartridges allows sample pre-concentration, enabling even low concentration analytes to be detected.

Owlstone Medical's Products and Services are for research use only. Not for use in diagnostic procedures.

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